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Zebrafish REGENERATION Model

Unlike what happens with mammals, the zebrafish is able to regenerate certain lost or injured tissues. In mammals, a trauma or injury usually produces permanent damage that can range from a simple scar to an amputation.

In recent years the zebrafish has become the object of scientific study all over the world due to various peculiarities that could inspire the development of future therapies very beneficial for the human being. Therefore Ikan Biotech has carried out internal R&D&I studies to know the regeneration capacity, focusing specifically on the regeneration of the caudal fin of the zebrafish.

Experimental model

 

The regeneration model is carried out in zebrafish adult stages from 4 to 6 months old. A blade amputates the caudal fin and over 15 days after amputation Ikan Biotech studies the regenerative process of the amputated limb as well as different genetic markers.

 

 

The objective of this study is to determine the effect of a compound when regenerating a complex tissue. During this process an inflammatory cell response is activated, macrophages and neutrophils migrate to the damaged area to initiate the tissue regeneration process. Similarly, there are different signaling pathways involved in modulating the immune response and regeneration itself. The study of the levels of gene expression in the regeneration area also allows to quantify the effect of compound with regenerative capacity.

Applicability of the model:

  • Determination of pro or anti-repair effects of new compounds
  • Study of inflammatory response
  • Study of tissue regeneration mechanisms

Coming next: zebrafish in the investigation of new therapies for inflammatory bowel diseases