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Based on many of the features of zebrafish model as performing non-invasive, high-resolution, long-term time-lapse and time-course experiments to visualize infection dynamics with fluorescent markers in the transparent embryo.

Ikan can generate preclinical models with:

  • Gram positive: Streptococcus equi, Streptococcus iniae, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus
  • Gram negative: Acinetobacter baumanii, Enterococcus faecalis, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Pseudomonas aeruginosa

Bacteremia / Sepsis

Ikan performs different assays for proliferation, survival and invasion.

  • Bacterial infection
  • Survival
  • Early innate immune response with qRT-PCR

Antimicrobial drug screening

Toxicity assays (safety and efficiency).

  • Effectiveness
  • Sustainability